Thermo Fisher Scientific BRCA1 Monoclonal Antibody (MS110)
BRCA1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, ICC, IP 등 다양한 응용에 적합하며, N-말단 영역(1–304 aa)에 결합합니다. 단백질 A로 정제된 액상 항체로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 | - |
| Immunohistochemistry (Frozen) (IHC-F) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MS110 |
| Immunogen | Recombinant full-length human BRCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536842 |
Product Specific Information
Antibody binding site (epitope) has been mapped within the N-terminal (1–304 amino acids) region of Human BRCA1.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC (BRCA1-associated genome surveillance complex) with other tumor suppressors, DNA damage sensors, and signal transducers.
BRCA1 interacts with RNA polymerase II and histone deacetylase complexes, contributing to transcription regulation, DNA double-strand break repair, and recombination.
Mutations in the BRCA1 gene account for ~40% of inherited breast cancers and >80% of inherited breast and ovarian cancers. Alternative splicing affects its subcellular localization and function, with multiple transcript variants and a related pseudogene on chromosome 17 identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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