Thermo Fisher Scientific Human IL-8 (CXCL8) Recombinant Protein
인간 IL-8(CXCL8) 재조합 단백질로 면역학적 분석의 양성 대조군으로 사용 가능. E. coli 발현 시스템에서 생산된 His-tag 단백질. 고순도(>95%)로 정제되어 있으며 액상 형태로 제공. 염증 반응 및 혈관신생 연구에 활용 가능.
- 카탈로그번호
- RP75610
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human IL-8 (CXCL8) Recombinant Protein
Applications
- Western Blot (WB): Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Amino acids Ala23–Ser99 containing an N-terminal His-tag |
| Tag | His-tag |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.16 mg/mL |
| Purification | Purified |
| Storage Buffer | 20 mM Tris HCl, pH 8, with 50% glycerol, 250 mM NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-75610 contains purified recombinant human IL-8 protein with an N-terminal hexahistidine tag.
RP-75610 may be used as a positive control in many immunological assays.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, which bind to the cell surface receptors IL-8RA and IL-8RB.
IL-8 functions as a chemoattractant and potent angiogenic factor. Its expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells.
In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature for IL-8 includes:
- Neutrophil activating protein 1 (NAP-1)
- Granulocyte chemotactic protein 1 (GCP-1)
- Monocyte-derived neutrophil-activating peptide (MONAP)
- Protein 3-10C
IL-8 and ten other members of the CXC chemokine gene family form a gene cluster mapped to chromosome 4q.
Cancer studies have demonstrated IL-8’s role in angiogenesis and tumor growth, and it is also implicated in bronchiolitis pathogenesis, a common viral respiratory tract disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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