Thermo Fisher Scientific Human IL-8 (CXCL8) Recombinant Protein

Thermo Fisher Scientific Human IL-8 (CXCL8) Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-75610 contains purified recombinant human IL-8 protein with an N-terminal hexahistidine tag.
RP-75610 may be used as a positive control in many immunological assays.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, which bind to the cell surface receptors IL-8RA and IL-8RB.
IL-8 functions as a chemoattractant and potent angiogenic factor. Its expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells.

In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.

Previous nomenclature for IL-8 includes:

• Neutrophil activating protein 1 (NAP-1)
• Granulocyte chemotactic protein 1 (GCP-1)
• Monocyte-derived neutrophil-activating peptide (MONAP)
• Protein 3-10C

IL-8 and ten other members of the CXC chemokine gene family form a gene cluster mapped to chromosome 4q.
Cancer studies have demonstrated IL-8’s role in angiogenesis and tumor growth, and it is also implicated in bronchiolitis pathogenesis, a common viral respiratory tract disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.