Thermo Fisher Scientific IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390)
IDH1 (R132H) 변이체에 특이적인 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. IHC(파라핀) 적용 가능하며, 고순도 Protein A 정제 및 안정적인 PBS/BSA/glycerol 버퍼로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM390 |
| Immunogen | A peptide corresponding to human IDH1 (R132H mutant specific), synthetic peptide within amino acids 180–280 of human IDH1 with R132H mutant |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2926715 |
Additional Formats
Target Information
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent (mitochondrial) and two NADP(+)-dependent (one mitochondrial, one cytosolic).
The NADP(+)-dependent cytosolic enzyme (encoded by IDH1) is a homodimer located in the cytoplasm and peroxisomes, containing a PTS-1 peroxisomal targeting signal.
It plays a role in regenerating NADPH for peroxisomal reductions and cytoplasmic NADPH production.
This antibody is specific for IDH1 (mutant R132H).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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