Thermo Fisher Scientific CD8 alpha Recombinant Rabbit Monoclonal Antibody (BLR173J)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family, playing an integral role in signal transduction and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also expressed as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation, which is crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: MA5-44531_CD8_P01731-1_Rabbit.svg, MA5-44531_CD8_P01731-1_Rabbit_PDP.jpeg)