Thermo Fisher Scientific CD8 alpha Recombinant Rabbit Monoclonal Antibody (BLR173J)
Thermo Fisher Scientific의 CD8 alpha recombinant rabbit monoclonal antibody (BLR173J)는 mouse CD8α 단백질을 인식하며, WB, IHC(P), IP에 적합합니다. HEK293 발현 시스템에서 생산된 정제 항체로, 4°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 12 µL / 1 mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR173J |
| Immunogen | Recombinant protein representing the extracellular domain of mouse T-cell surface glycoprotein CD8 alpha (residues 28–194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2926661 |
Product Specific Information
Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family, playing an integral role in signal transduction and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also expressed as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation, which is crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-44531_CD8_P01731-1_Rabbit.svg, MA5-44531_CD8_P01731-1_Rabbit_PDP.jpeg)
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