Thermo Fisher Scientific PTBP1 Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all hnRNPs are present in the nucleus, some shuttle between the nucleus and cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four quasi-RNA recognition motif (RRM) domains that bind RNAs. It binds to intronic polypyrimidine tracts required for pre-mRNA splicing and acts via the ubiquitin-proteasome pathway. It may promote the binding of U2 snRNP to pre-mRNAs. The protein is localized in the nucleoplasm and detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

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