Thermo Fisher Scientific MC4R Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  Tested Dilution: 2.5–5 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Sheep, Rabbit (100%).

Target Information

Expression of MC4R has been reported in the brain. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices.
GPCRs exist in active and inactive forms, with activating ligands inducing conformational changes leading to signaling via G-proteins and downstream effectors.
Negative regulation of GPCRs plays an important physiological role and continues to drive pharmacological research for new drug candidates.
Notably, GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) have achieved significant market success in mental health and allergy treatments.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.