Thermo Fisher Scientific MC4R Polyclonal Antibody
MC4R 단백질을 인식하는 토끼 폴리클로날 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간, 말, 영장류에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 용액 내 0.1% sodium azide 포함, 4°C 단기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
| Immunocytochemistry (ICC/IF) | 7.5–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human MC4 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551293 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Horse (100%).
Target Information
Expression of MC4R has been reported in brain. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices. GPCRs exist in active and inactive forms, with various ligands influencing their conformation and signaling via G-proteins and downstream effectors.
Negative regulation mechanisms of GPCRs are crucial for cellular physiology and are key targets in pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) highlight their therapeutic importance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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