Thermo Fisher Scientific PKP2 Monoclonal Antibody (8H6)
PKP2 단백질을 인식하는 마우스 단클론 항체로 Western blot, IHC, ICC, Flow cytometry 등에 사용 가능. 인간 및 마우스 반응성. 단백질 A 정제, 1 mg/mL 농도, PBS 용액에 0.1% sodium azide 포함. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:100 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent | |
| Flow Cytometry (Flow) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8H6 |
| Immunogen | Recombinant fragment corresponding to amino acids 1–350 of Human Plakophilin 2 fused to maltose binding protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539464 |
Product Specific Information
This target has a predicted molecular weight of 97 kDa.
Target Information
Plakophilins 1, 2, 3, and 4 (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. These proteins contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes—cell-cell junctions found in suprabasal layers of stratifying epithelia subject to mechanical stress.
Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
Plakophilin 2 is critical for desmosome assembly and serves as an essential morphogenic factor and architectural component of the heart.
Plakophilin 4 contributes to desmosomal adhesion plaque structure and regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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