Thermo Fisher Scientific PDZK1 Polyclonal Antibody
PDZK1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC 등 다양한 응용에 사용 가능. 사람, 마우스, 소 시료에 반응하며 rat에는 비반응성. 세포막 단백질 발현 및 조절 연구에 적합. 연구용으로만 사용.
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- PA316818
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to the C-terminus of human PDZK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2162811 |
Product Specific Information
This antibody does not react with rat samples.
Target Information
PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cell apical domains. It may coordinate diverse regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster interdependent proteins and modulate trafficking and activity of associated membrane proteins. PDZK1 may also play a role in multidrug resistance mechanisms through interactions with ABCC2 and PDZK1IP1 and may potentiate CFTR chloride channel activity. It connects SCARB1 with intracellular cholesterol transport and may regulate proximal tubular Na(+)-dependent phosphate cotransport, contributing to tubule function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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