Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI13F12), TrueMAB
인간 Ki-67 단백질을 인식하는 마우스 단클론 항체로, 세포 증식 마커 연구에 적합합니다. 포르말린 고정 파라핀 절편(IHC-P)에 최적화되어 있으며, 동결 건조 형태로 제공됩니다. 1 mg/mL 농도, PBS 버퍼(8% 트레할로스) 포함, -20°C 보관.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC-P)
Recommended Dilution
- 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13F12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Ki-67 is a nuclear protein expressed during active phases of the cell cycle (late G1, S, G2, and M phases).
It associates with euchromatin, centromeric heterochromatin, and the nucleolus through its FHA domain.
Expression patterns vary by cell cycle phase:
- Perinucleolar expression in G1
- Nuclear matrix localization in G2
- Chromosomal association during M phase
Ki-67 is widely used as a proliferation marker since it is absent in G0 cells and increases from G1 through mitosis.
It helps determine the growth fraction in neoplasms, correlating with tumor grade and prognosis.
Commonly used as a neuronal marker for cell cycling and proliferation studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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