Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI16E9), TrueMAB
인간 Ki-67 단백질을 인식하는 단클론 항체로, 세포 증식 마커 연구에 적합합니다. IHC(P)에서 1:100 희석으로 사용 가능하며, 동결건조 형태로 제공됩니다. PBS 버퍼에 8% 트레할로스 포함, -20°C에서 보관합니다.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI16E9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly in late G1, S, G2, and M phases. It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus through its forkhead-associated (FHA) domain.
- Ki-67 shows cell cycle–dependent localization: perinucleolar in G1, nuclear matrix in G2, and chromosomal during M phase.
- Commonly used as a proliferation marker since it is absent in G0 cells and increases from G1 through mitosis.
- Useful for determining the proliferative fraction in neoplasms and correlates with tumor grade.
- Routinely used as a neuronal marker of cell cycling and proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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