Thermo Fisher Scientific CD307e (FcRL5) Monoclonal Antibody (509F6), eFluor 660, eBioscience
인간 CD307e(FcRL5)를 인식하는 509F6 단클론 항체로, eFluor 660 형광 표지된 Flow Cytometry용 항체입니다. 성숙 B세포 및 형질세포 표면 단백질 분석에 적합하며, 암 관련 연구 및 면역학적 분석에 활용됩니다. 4°C 암실 보관, 동결 금지.
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Thermo Fisher Scientific CD307e (FcRL5) Monoclonal Antibody (509F6), eFluor 660, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (1 µg)/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 509F6 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574199 |
Product Specific Information
The 509F6 monoclonal antibody reacts with human CD307e (Fc receptor-like 5, FcRL5, FcRH5, IRTA2).
CD307e is a surface protein selectively expressed on naive mature B cells and bone marrow plasma cells, binding all IgG isotypes.
It acts as an inhibitory coreceptor on mature B cells via SHP-1 recruitment to ITIM motifs.
Soluble CD307e levels are elevated in multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma, making it a potential therapeutic target.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells
Use 5 µL (1 µg) per test in 100 µL final volume. Cell number range: 10⁵–10⁸ cells/test.
Fluorochrome Information:
eFluor® 660 replaces Alexa Fluor® 647.
Emission: 659 nm; Excitation: 633 nm (Red Laser).
Ensure instrument compatibility.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Fc receptor homologs (FcRH5, IRTA2) are transmembrane proteins homologous to classical Fc receptors.
They function as activating or inhibitory receptors on distinct B cell populations, involved in B-cell development and differentiation.
FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities, suggesting a role in B-cell lymphoma pathogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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