Thermo Fisher Scientific CD300f (IREM-1) Monoclonal Antibody (UP-D1), eFluor 660, eBioscience
인간 CD300f(IREM-1)을 인식하는 UP-D1 단클론 항체로, eFluor 660 형광 표지되어 있습니다. 유세포 분석(Flow Cytometry)에 최적화되어 있으며, 마이엘로이드 세포 표면 단백질 연구에 적합합니다. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UP-D1 |
| Conjugate | eFluor™ 660 |
| Excitation/Emission Max | 651/668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574195 |
Product Specific Information
The monoclonal antibody recognizes human IREM-1 (Immune receptor expressed by myeloid cell 1), also known as CD300f.
IREM-1 is a type I transmembrane protein with a single Ig domain and a long cytoplasmic tail containing an ITIM domain, functioning as an inhibitory receptor. The cytoplasmic domain interacts with SHP-1 and the p85α subunit of PI3K.
Expression is restricted to myeloid cells, including monocytes and granulocytes, and is downregulated in monocyte-derived dendritic cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and validated for normal human peripheral blood cells at 5 µL (0.125 µg) per test
- A test = staining a cell sample in 100 µL final volume
- Suitable for 10⁵–10⁸ cells/test
eFluor® 660 replaces Alexa Fluor® 647.
- Emission: 659 nm
- Excitation: 633–647 nm (Red Laser)
- Ensure the instrument detects this fluorochrome.
- Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CLM1 (CD300f) is an inhibitory receptor of the Ig superfamily expressed on myeloid cells.
It mediates negative regulatory signals by recruiting SHP1 (PTPN6) or SHIP.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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