Thermo Fisher Scientific CD45 Monoclonal Antibody (EM-05)
쥐 CD45 항원을 인식하는 단클론 항체로, Western blot, ICC/IF, Flow cytometry, Immunoprecipitation에 사용 가능. 비결합형 액상 형태이며 Protein A로 정제됨. 혈액세포 표지 및 면역세포 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-05 |
| Immunogen | Murine peripheral blood leukocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156009 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of murine CD45 antigen (Leukocyte Common Antigen), a single-chain type I transmembrane protein expressed at high levels on hematopoietic cells except erythrocytes and platelets.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of lymphocyte surface proteins. It is absent in non-hematopoietic cells and tissues. CD45 plays a critical role in lymphocyte development and antigen signaling by regulating Src-family kinases and JAK kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions. CD45 is essential for T- and B-cell receptor signaling, cytokine receptor regulation, and integrin-mediated survival pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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