Thermo Fisher Scientific CD45 Monoclonal Antibody (EM-05), PE
마우스 CD45 항원을 인식하는 단클론 항체로, PE 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, Rat IgG 아이소타입입니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 암소 보관합니다.
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Applications
- Flow Cytometry (Flow): 1–2 µg/mL
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-05 |
| Immunogen | Murine peripheral blood leukocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153376 |
Available Formats
Product Specific Information
This antibody reacts with an extracellular epitope of murine CD45 antigen (Leukocyte Common Antigen), a single-chain type I transmembrane protein expressed at high levels on cells of hematopoietic origin, except erythrocytes and platelets.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes.
It is absent on non-hematopoietic cell lines and tissues. CD45 plays a crucial role in lymphocyte development and antigen signaling by regulating Src-family kinases.
Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions.
CD45 is essential for T- and B-cell receptor signaling, JAK kinase regulation, and modulation of integrin-mediated signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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