Thermo Fisher Scientific CD45 Monoclonal Antibody (EM-05), PerCP
Flow Cytometry용 PerCP 형 CD45 단클론 항체로, 마우스 CD45 항원을 인식합니다. Rat IgG 형식이며, 4°C 암소 보관이 필요합니다. 형광 최대치는 482/675 nm이며, 세포 표면 CD45 검출에 적합합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 2–4 µg/mL
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-05 |
| Immunogen | Murine peripheral blood leukocytes |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152832 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of murine CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high levels on hematopoietic cells except erythrocytes and platelets.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells. It constitutes approximately 10% of lymphocyte surface proteins and is absent in non-hematopoietic cells and tissues.
CD45 regulates Src-family kinases and JAK kinases, playing a key role in lymphocyte development, antigen signaling, and cytokine receptor regulation.
It also modulates integrin-mediated signaling, apoptosis, and various immune functions. Multiple isoforms exist due to alternative splicing, differing in extracellular domains while sharing transmembrane and cytoplasmic regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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