Thermo Fisher Scientific Human KREMEN2 Synthetic Peptide
인간 KREMEN2 단백질의 C-말단 15 아미노산 서열로 구성된 합성 펩타이드. PA5-34525 항체의 블로킹 펩타이드로 사용 가능. Wnt 신호전달 조절 연구에 활용. 순도 높고 PBS 완충액에 보관되는 액상 형태.
- 카탈로그번호
- PEP1568
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human KREMEN2.
PEP-1568 can be used as a blocking peptide with polyclonal antibody PA5-34525.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC, and CUB domains, and an intracellular region without any conserved motifs.
Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor.
Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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