Thermo Fisher Scientific IL4R Recombinant Rabbit Monoclonal Antibody (R001)

Applications

Tested Dilution

Publications

Neutralization (Neu)

0.2 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

R001

Immunogen

Recombinant Human IL-4R/CD124 Protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.40 mg/mL

Purification

Protein A

Storage buffer

arginine/histidine with 0.02% Tween 80, 120mM NaCl

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912255

Product Specific Information

Specificity: Human IL-4R/CD124

Target Information

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.