Thermo Fisher Scientific IL-23 p19 Chimeric Recombinant Human Monoclonal Antibody (mh066)

Applications

Tested Dilution

Publications

Neutralization (Neu)

10 ng/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Human / IgG1

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

mh066

Immunogen

Recombinant Human IL23A and Mouse IL12B Heterodimer Protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.25 mg/mL

Purification

Protein A

Storage buffer

arginine/histidine with 0.02% Tween 80, 120mM NaCl

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912256

Product Specific Information

Specificity: Human IL23A and Human IL12B Heterodimer. This product is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The antibody was produced using recombinant antibody technology.

Target Information

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.