Thermo Fisher Scientific IL-22 Polyclonal Antibody, Biotin
Human IL-22 단백질에 특이적인 Biotin 결합 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합. 고순도 Ion-exchange chromatography 정제. 장기 보관 시 -20°C에서 안정적으로 유지. 연구용으로만 사용 가능.
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Thermo Fisher Scientific IL-22 Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1:20,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-IL-22 antibody was prepared from rabbit antiserum after repeated immunizations with a truncated form of recombinant human IL-22 protein from E. coli. |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 10 mg/mL BSA, 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid; dilute only prior to immediate use.
- Anti-IL-22 is an IgG fraction purified from monospecific antiserum via delipidation, salt fractionation, and ion-exchange chromatography followed by extensive dialysis.
- Specific for human IL-22 protein. BLAST analysis suggests 100% homology with human IL-22 sequence.
- Immunoelectrophoresis shows a single precipitin arc against anti-Biotin and anti-Rabbit Serum.
- Cross-reactivity with IL-22 from other species has not been determined.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and member of the IFN–IL-10 family (IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, the IL-22 gene is located on chromosome 12q and structurally related to IL-10.
It binds a heterodimeric receptor complex (IL-22R1 and IL-10R2) to activate JAK-STAT signaling.
IL-22BP acts as a soluble antagonist.
Major targets are nonimmune cells such as keratinocytes, hepatocytes, and epithelial cells.
IL-22, co-expressed with IL-17A and IL-17F by Th17 cells, regulates innate immunity genes and promotes wound healing and defense against extracellular pathogens.
It is upregulated in activated T cells and mediates IL-23-induced dermal inflammation via STAT3 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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