Thermo Fisher Scientific TAB2 Polyclonal Antibody
Human TAB2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:500–1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관. TAB2 관련 신호전달 및 자가포식 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human TAB2. Recombinant protein control fragment (Product # RP-108562) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857067 |
Product Specific Information
Immunogen sequence:
HSGWVSQFNP MNPQQVYQPS QPGPWTTCPA SNPLSHTSSQ QPNQQGHQTS HVYMPISSPT TSQPPTIHSS
Target Information
TAB2 is an activator of MAP3K7/TAK1, required for IL-1–induced activation of NF-κB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL-induced signal transduction via TNFRSF11A/RANK, regulating osteoclast development and function.
TAB2 and TAB3 interact with the autophagy mediator Beclin-1; upon induction of autophagy, they dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that these proteins act as control points for autophagy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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