Thermo Fisher Scientific MKNK2 Polyclonal Antibody
Human MKNK2 단백질에 특이적인 Rabbit Polyclonal 항체로, ICC/IF에 0.25–2 µg/mL 농도로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. eIF4E 인산화 연구 및 종양 관련 단백질 발현 분석에 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human MKNK2. Recombinant protein control fragment (Product #RP-106497) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857069 |
Product Specific Information
Immunogen sequence:
AIAMNRQLAQ HDEDLAEEEA AGQGQPVLVR ATSRCLQLSP PSQSKLAQ
Target Information
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, acting as an eIF-4E kinase in vivo. Mnk2 may play roles in environmental stress and cytokine response. Expression of active mutants of MNK1 and MNK2 in 293 cells reduces cap-dependent translation relative to cap-independent translation in transient reporter assays. Human Mnk2 shares high homology with murine Mnk2 (≈94%) and human Mnk1 (≈71%). In vitro studies indicate Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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