Thermo Fisher Scientific Phospho-Tau (Ser199) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Cerebrum tissue
• Cellular location: Cytoplasm, cytosol, membrane

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is influenced by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms support stabilization. In its hyper-phosphorylated form, Tau constitutes the paired helical filaments (PHF) that form neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau is also observed in other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.