Thermo Fisher Scientific Phospho-Tau (Ser199) Polyclonal Antibody
Phospho-Tau (Ser199) 특이적 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. Tau 단백질의 인산화 연구에 적합합니다.
- 카탈로그번호
- 620-660
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the sequence YSSPG of human Tau protein with a phosphorylation site at Serine 199 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cerebrum tissue
- Cellular location: Cytoplasm, cytosol, membrane
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is influenced by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.
Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms support stabilization. In its hyper-phosphorylated form, Tau constitutes the paired helical filaments (PHF) that form neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau is also observed in other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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