Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI5A3), TrueMAB
인간 N4BP2L2 단백질을 인식하는 Mouse IgG2a 단클론 항체로 Western blot에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 저장용액. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A3 |
| Immunogen | Full length human recombinant protein of N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, probably by ATM or ATR.
Primarily expressed in bone marrow, N4BP2L2 is down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders.
Defects in Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, leading to decreased neutrophil counts and increased infection risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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