Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI3F12), TrueMAB
인간 N4BP2L2 단백질을 인식하는 마우스 단클론 항체로, Western blot에 적합합니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능하며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F12 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, probably by ATM or ATR. It is primarily expressed in bone marrow and is dramatically down-regulated after exposure to arsenic compounds, an event that precedes neutropenia.
PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, leading to decreased circulating neutrophils and increased risk of opportunistic infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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