Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI3G7), TrueMAB
Thermo Fisher Scientific의 N4BP2L2 단클론 항체(OTI3G7)는 인간 N4BP2L2 단백질을 특이적으로 인식하는 Mouse IgG1 TrueMAB 제품입니다. Western blot에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G7 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. It is primarily expressed in bone marrow and is dramatically down-regulated after exposure to arsenic compounds, preceding neutropenia. PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, leading to reduced circulating neutrophils and increased risk for opportunistic infection.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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