Thermo Fisher Scientific TMC6 Polyclonal Antibody
Thermo Fisher Scientific의 TMC6 폴리클로날 항체는 인간, 마우스, 랫트에서 반응하며 Western blot 및 IHC에 적합합니다. Rabbit IgG로 제작된 비결합형 액상 항체로, 항원 친화 크로마토그래피로 정제되었습니다. EVER1 N말단 펩타이드 기반 면역원 사용.
- 카탈로그번호
- PA520504
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the amino terminus of human EVER1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155186 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20504 can be used with blocking peptide PEP-0624.
Target Information
TMC6 interacts with and forms a complex with the zinc transporter 1 (SLC30A1), localizing to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene is implicated in epidermodysplasia verruciformis (EV), an autosomal recessive skin disorder characterized by abnormal susceptibility to human papillomaviruses (HPVs) and increased risk of squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in two adjacent genes on chromosome 17q25.3.
TMC6 encodes integral membrane proteins predicted to form transmembrane channels with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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