Thermo Fisher Scientific AIFM3 Polyclonal Antibody

Thermo Fisher Scientific AIFM3 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1–2 µg/mL
Publications: -

Product Specifications

Product Specific Information

• Suggested positive control: Human brain tissue lysate
• PA5-20503 can be used with blocking peptide PEP-0623

Target Information

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently, a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3).
AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induces cytochrome c release from mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation.
Multiple isoforms of AIFM3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.