Thermo Fisher Scientific AIFM3 Polyclonal Antibody
AIFM3 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 시료에 반응하며 Western blot에 적합. 항원 친화 크로마토그래피로 정제된 액상형 항체로 안정적 저장 가능.
- 카탈로그번호
- PA520503
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific AIFM3 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1–2 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the center of human AIFM3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153465 |
Product Specific Information
- Suggested positive control: Human brain tissue lysate
- PA5-20503 can be used with blocking peptide PEP-0623
Target Information
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently, a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3).
AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induces cytochrome c release from mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation.
Multiple isoforms of AIFM3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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