Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Monoclonal Antibody (NEUN/7168)
신경세포 특이적 마커인 NeuN을 인식하는 단클론 항체로, 인간 시료에 반응합니다. 파라핀 절편 및 PFA 고정 조직의 면역조직화학(IHC)에 적합합니다. 단백질 A/G로 정제된 액상 항체이며 보존제가 없습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NEUN/7168 |
| Immunogen | Recombinant fragment (around aa1–200) of human RBFOX3 (NeuN) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein that contains one RRM (RNA recognition motif) domain. Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which accounts for over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17: p53 and BRCA1.
- p53: Maintains cellular genetic integrity by mediating DNA repair or cell death; its loss is linked to malignant growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and associated with early-onset breast, ovarian, colon, prostate, and fallopian tube cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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