Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (NeuN/288R)
NeuN(Neuronal Marker)을 인식하는 재조합 토끼 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. Western Blot 및 면역조직화학(IHC) 실험에 적합하며, 고순도 Protein A/G 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (NeuN/288R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NeuN/288R |
| Immunogen | Recombinant full-length human NeuN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which accounts for over 2.5% of the human genome and encodes more than 1,200 genes.
Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.
- p53: Maintains genetic integrity by moderating cell fate through DNA repair versus apoptosis. Loss or malfunction of p53 leads to malignant growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and recognized as a genetic determinant of early-onset breast cancer and predisposition to cancers of the ovary, colon, prostate, and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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