Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Monoclonal Antibody (NEUN/7168)
신경세포 특이적 마커 NeuN을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. IHC(P) 및 IHC(PFA) 실험에 적합하며, 고순도 Protein A/G 정제 및 200 µg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NEUN/7168 |
| Immunogen | Recombinant fragment (around aa1–200) of human RBFOX3 (NeuN) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein that contains one RRM (RNA recognition motif) domain.
Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes.
Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.
- p53: Maintains cellular genetic integrity via DNA repair and apoptosis regulation.
- BRCA1: Involved in DNA repair and associated with early-onset breast and other cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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