Thermo Fisher Scientific ARHGEF3 Polyclonal Antibody
ARHGEF3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 완충액에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human ARHGEF3 (amino acids 480–502) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635569 |
Product Specific Information
This antibody detects endogenous levels of total ARHGEF3 protein.
Target Information
Rho-like GTPases are involved in various cellular processes and are activated by GTP binding and inactivated by GTP hydrolysis. Guanine nucleotide exchange factors (GEFs) promote this process by catalyzing the release of GDP.
The ARHGEF3 gene encodes a GEF that specifically activates RHOA and RHOB, both important in bone cell biology. Genetic variation in this gene has been linked to bone mineral density (BMD) and postmenopausal osteoporosis. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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