Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total ARHGEF11 protein.

Target Information

ARHGEF11 is a 1527 amino acid protein containing tandem Dbl homology and pleckstrin homology domains, a PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It functions as a guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42, and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
ARHGEF11 forms complexes with G proteins and stimulates neurite retraction through Rho-dependent signaling. It increases glutamate transport fourfold, interacts with EAAT4, and modulates uptake activity and perisynaptic distribution at glutamatergic synapses.
Overexpression induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation. It is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.