Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody
ARHGEF11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot에 적합하며 인간 단백질에 반응. 항원 친화 크로마토그래피로 정제, PBS/glycerol buffer에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA550114
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from N-terminal of human ARHGEF11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635567 |
Product Specific Information
This antibody detects endogenous levels of total ARHGEF11 protein.
Target Information
ARHGEF11 is a 1527 amino acid protein containing tandem Dbl homology and pleckstrin homology domains, a PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It functions as a guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42, and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
ARHGEF11 forms complexes with G proteins and stimulates neurite retraction through Rho-dependent signaling. It increases glutamate transport fourfold, interacts with EAAT4, and modulates uptake activity and perisynaptic distribution at glutamatergic synapses.
Overexpression induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation. It is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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