Thermo Fisher Scientific MHC Class II Monoclonal Antibody (YKIX334.2), FITC

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: Neat
  • Publications: View 1 publication

Product Specifications

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Rat anti-Dog MHC Class II Monomorphic antibody, clone YKIX334.2 recognizes a monomorphic epitope on canine MHC Class II and was classified at the First Canine Leucocyte Antigen Workshop (Cobbold et al. 1994).

Target Information

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells, and B cells. Before their expression on the cell surface, MHC class II molecules react with endocytosed exogenous antigens, which are then presented to T cells.
The antigen-binding groove between the MHC class II alpha and beta chains is open at both ends and is 15–24 amino acid residues long.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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