Thermo Fisher Scientific PDE2A Recombinant Rabbit Monoclonal Antibody (201)

Applications

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human PDE2A.

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kDa cyclic nucleotide phosphodiesterase (PDE). Three isoforms (PDE2A1, PDE2A2, PDE2A3) arise from a single gene by alternative splicing. PDE2A degrades both cAMP and cGMP, with higher efficacy for cGMP. It is expressed in various tissues, with the highest expression in the brain, particularly in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial barrier.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.