Thermo Fisher Scientific OLFM4 Monoclonal Antibody (02)

Applications

ELISA

• Tested Dilution: 1:1,000–1:2,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human OLFM4/GW112.

Target Information

OLFM4 is a 510 amino acid extracellular matrix glycoprotein belonging to the olfactomedin-related protein family and found to be selectively expressed in inflamed colonic epithelium. It has one signal peptide, six N-linked glycosylation motifs, and forms disulfide-bonded multimers. OLFM4 may have a matrix-related function in differentiation.
Constitutively expressed OLFM4 in cancer cells binds to the potent apoptosis inducer GRIM-19 and exhibits antiapoptotic action, potentially serving as a diagnostic marker for human cancers. Reports suggest that OLFM4 promotes proliferation of PANC-1 cells by favoring transition from the S to G2/M phase. Interaction with endogenous cell surface lectins and cadherins may mediate cell adhesion.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.