Thermo Fisher Scientific CXCR3 Polyclonal Antibody
CXCR3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간과 랫트 반응성. 친화 크로마토그래피로 정제된 액상 형태로, 안정적인 보관 및 재현성 높은 결과 제공.
- 카탈로그번호
- CXCR3-312AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of human CXCR3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a G protein-coupled receptor selective for three chemokines: IP10 (interferon-γ-inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T cell α-chemoattractant). These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two conserved cysteines.
Binding of chemokines to CXCR3 induces cellular responses involved in leukocyte trafficking, integrin activation, cytoskeletal rearrangement, and chemotaxis. The receptor is coupled to Gi-type G proteins, and signal transduction likely involves enzymes shared with other chemokine receptor pathways.
CXCR3 expression is prominent in effector/memory T cells and T cells from inflamed tissues. IP10, Mig, and I-TAC are often produced locally in inflammatory lesions, implicating CXCR3 in inflammatory cell recruitment. Thus, CXCR3 is a therapeutic target for small-molecule antagonists aimed at treating inflammatory diseases. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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