Thermo Fisher Scientific CXCR3 Polyclonal Antibody, Biotin
CXCR3 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간 및 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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- CXCR3H-BIOTIN
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of human CXCR3 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CXCR3 gene encodes a G protein–coupled receptor selective for three chemokines: IP10 (interferon-γ–inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T cell α-chemoattractant). These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two conserved cysteine residues.
Binding of these chemokines to CXCR3 triggers cellular responses such as leukocyte trafficking, integrin activation, cytoskeletal reorganization, and chemotaxis. The receptor couples to Gi-class heterotrimeric G proteins, and its signaling cascade resembles other chemokine receptors. Following ligand-induced internalization, receptor recycling restores responsiveness.
CXCR3 is prominently expressed in effector/memory T cells and T cells in inflamed tissues. IP10, Mig, and I-TAC are locally produced in inflammatory lesions, implicating CXCR3 in inflammatory cell recruitment. Consequently, CXCR3 is a potential therapeutic target for inflammatory disease modulation. Multiple transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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