Thermo Fisher Scientific E-cadherin Monoclonal Antibody (67A4), APC

Thermo Fisher Scientific E-cadherin Monoclonal Antibody (67A4), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 10 µL / 1×10⁶ cells
Publications: - References

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.

Target Information

E-Cadherin (epithelial cadherin) is a calcium-dependent cell-cell adhesion glycoprotein belonging to the cadherin superfamily. The protein contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in the CDH1 gene (chromosome 16) are associated with various cancers such as gastric, breast, colorectal, thyroid, and ovarian cancer. Loss of E-cadherin function contributes to tumor progression by enhancing proliferation, invasion, and metastasis. E-cadherin also mediates bacterial adhesion and is essential for maintaining epithelial integrity and tissue architecture.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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