Thermo Fisher Scientific CD34 Monoclonal Antibody (581)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-Dependent

Flow Cytometry (Flow)

• 1–4 µg/mL
• View 4 publications

Miscellaneous PubMed (Misc)

• View 2 publications

Product Specifications

Available Conjugated Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes the class III CD34 epitope resistant to neuraminidase, chymopapain, and glycoprotease.

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on many stem cell populations. It serves as a stem cell marker with reversible expression on human hematopoietic stem cells. CD34 may function as a surface receptor involved in receptor-mediated endocytosis, adhesion, differentiation, and proliferation of hematopoietic stem and progenitor cells. It may mediate attachment to the bone marrow extracellular matrix or stromal cells and act as a scaffold for lineage-specific glycans, facilitating interactions with lectins and selectins. The intracellular domain is phosphorylated by protein kinase C, suggesting a role in signal transduction. CD34 dysfunction is associated with dermatofibrosarcoma and neurofibroma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.