Thermo Fisher Scientific CD34 Monoclonal Antibody (QBEND/10)
CD34 단백질을 표적으로 하는 QBEND/10 클론 단일클론 항체로, 인간 및 비인간 영장류 시료에 반응합니다. Western blot, IHC, Flow cytometry 등 다양한 실험에 사용 가능하며, 단백질 A로 정제된 액상 형태입니다. 보존제 없이 PBS(pH 7.4)에 보관되며 4°C에서 저장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 155 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–8 µg/mL | View 4 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | – |
| Immunocytochemistry (ICC/IF) | – | View 13 publications |
| Flow Cytometry (Flow) | 5 µg/mL | View 6 publications |
| Immunoprecipitation (IP) | Assay-dependent | – |
| Functional Assay | Assay-dependent | – |
| Miscellaneous PubMed | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Bovine, Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | QBEND/10 |
| Immunogen | Human endothelial vesicles |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156010 |
Available Conjugates:
Product Specific Information
This antibody reacts with an extracellular class II epitope on CD34, a 110–115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitor cells and pluripotent stem cells. Expression is gradually lost on progenitor cells. It is also used as an endothelial marker.
- No cross-reactivity with rat, bovine, canine, or sheep.
- Functional Application: Induction.
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It functions as a stem cell marker and may regulate adhesion, differentiation, and proliferation of hematopoietic stem cells. CD34 likely mediates attachment of stem cells to the bone marrow matrix or stromal cells and may act as a scaffold for glycans binding to lectins. The intracellular domain is phosphorylated by activated protein kinase C, suggesting a role in signal transduction.
Associated diseases: dermatofibrosarcoma, neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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