Thermo Fisher Scientific NR5A1 Polyclonal Antibody
Human NR5A1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.7 mg/mL 농도의 액상 형태입니다. PBS 버퍼에 0.1% sodium azide를 포함하며, 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 2.5–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from near C-terminus of human NR5A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550411 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human (100%); Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Elephant, Rabbit, Opossum (94%); Panda, Horse, Pig, Turkey, Chicken (88%); Platypus (82%). - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 is essential for fetal development of the hypothalamus, pituitary gland, gonads, and adrenal gland. It promotes transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family.
SF-1 contains two activation function domains (AF1 and AF2), common to many nuclear steroid receptors, which are necessary for interaction with other nuclear receptors and coactivators/corepressors such as:
- Steroid receptor coactivator-1 (SRC-1)
- Glucocorticoid receptor interacting protein 1 (GRIP1)
- cAMP response element binding protein (CREB) binding protein (CBP)
- Silencing mediator of retinoid acid and thyroid hormone receptor (SMRT)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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