Thermo Fisher Scientific Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
Phospho-IRE1 alpha (Ser724) 폴리클로날 항체로, Western blot에 최적화되어 있으며 Rat 종에서 검증됨. ER 스트레스 관련 IRE1 신호전달 연구에 적합. 농도 0.84 mg/mL, 장기 보관 시 -20°C에서 저장 권장.
- 카탈로그번호
- PA585647
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human IRE1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.84 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792787 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Japanese Medaka (100%)
- Positive Control: 293T, HepG2
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities and plays an essential role in endoplasmic reticulum-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating the unfolded protein response by splicing XBP1 mRNA into an active transcriptional activator. ERN1 controls IRE1 proteolysis in mammalian cells and has critical functions in extraembryonic cells essential for fetal viability. Null mutants are viable but IRE1 is essential under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through dominant negative expression leads to apoptosis under such stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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