Thermo Fisher Scientific P-cadherin Polyclonal Antibody
Rabbit polyclonal antibody targeting human P-cadherin (Cadherin-3). Validated for WB, IHC(P), and ICC/IF applications. Lyophilized form, reconstitutable to 500 µg/mL. Ideal for research on cell adhesion and cadherin signaling pathways.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human P-cadherin (612–626 aa, QDTYDVHLSLSDHGN) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746139 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
P-cadherin (Cadherin-3) is a Type I cadherin protein belonging to the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein involved in development, wound healing, and cell signaling.
P-cadherin is expressed in fetal tissues and adult structures such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. It is also found in embryonic stem cells and mammary gland stem cells.
Overexpression is linked to poor prognosis in various carcinomas including breast, prostate, ovary, colon, and stomach cancers. Mutations in CDH3 are associated with congenital hypotrichosis with juvenile macular dystrophy.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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