Thermo Fisher Scientific CDC37 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CDC37 protein. Validated for Western blot (0.1–0.5 µg/mL). Supplied lyophilized, reconstitutable to 500 µg/mL. Purified by antigen affinity chromatography and stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human Cdc37 recombinant protein (Position: M216–V378) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746136 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
Cdc37 has been shown to interact with HSP90 and is the same protein previously described as p50. Cdc37/p50 forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src. It acts as a molecular chaperone both independently and in concert with HSP90, and is necessary for the binding of HSP90 to Cdk4.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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