Thermo Fisher Scientific TLR2 Monoclonal Antibody (6C2)

Thermo Fisher Scientific TLR2 Monoclonal Antibody (6C2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA1-40048 detects TLR2 from mouse samples.
It has been successfully used in flow cytometry, immunoprecipitation, immunohistochemistry (frozen), and immunofluorescence applications.
The immunogen is mouse TLR2/CD282.

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins.
TLRs are highly conserved across species and exhibit distinct expression patterns.
TLR2 is abundantly expressed in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast via NF-kappaB stimulation.
It recognizes pathogen-associated molecular patterns (PAMPs) and induces cytokine production for effective immunity.
TLR2 expression is found in human tonsils, microglia, lymph nodes, appendices, and activated B-cells.
CD14+ monocytes express the highest level of TLR2, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.
Expression is regulated by immune response modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-gamma, and TNF downregulate its expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.