Thermo Fisher Scientific CD11b Monoclonal Antibody (5C6), FITC

Thermo Fisher Scientific CD11b Monoclonal Antibody (5C6), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat
Publications: -

Product Specifications

Additional Formats

• Unconjugated
• PE
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Rat anti Mouse CD11b antibody, clone 5C6 recognizes CD11b, also known as the integrin alpha M chain.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18).
The CD11b/CD18 heterodimeric complex, also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3), is expressed on:

• Monocytes/macrophages
• Granulocytes
• Activated lymphocytes
• A subset of NK cells
• A subset of dendritic cells
• Microglia in the brain

CD11b/CD18 acts as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
These interactions are critical for cell-cell and cell-matrix adhesion. CD11b expression increases during monocyte maturation and varies among tissue macrophages. Peritoneal macrophages express higher levels of CD11b than splenic macrophages.

Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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