Thermo Fisher Scientific alpha-ENaC Polyclonal Antibody
Rabbit polyclonal antibody targeting alpha-ENaC for IHC applications. Recognizes extracellular domain of human SCNN1A. Suitable for kidney, lung, and epithelial sodium channel studies. Lyophilized form, stored at 4°C or -20°C.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from extracellular domain of human SCNN1A conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2184370 |
Product Specific Information
SCNN1 is highly expressed in kidney and lung tissues, detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta.
Isoform 1 and 2 are predominant in all tissues.
Expression of isoform 3, 4, and 5 is very low or not detectable, except in lung and heart tissues.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels possess two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, gamma). ENaC in kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance.
It mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, regulating blood pressure.
ENaC is thought to be regulated partly through association with the CFTR chloride ion channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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