Thermo Fisher Scientific alpha-ENaC Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Product Specifications

Product Specific Information

SCNN1 is highly expressed in kidney and lung tissues, detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta.
Isoform 1 and 2 are predominant in all tissues.
Expression of isoform 3, 4, and 5 is very low or not detectable, except in lung and heart tissues.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels possess two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, gamma). ENaC in kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance.
It mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, regulating blood pressure.
ENaC is thought to be regulated partly through association with the CFTR chloride ion channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.