Thermo Fisher Scientific CD8a Monoclonal Antibody (OX8), eBioscience
Rat CD8α 인식 단클론 항체(OX8)로, Flow Cytometry 및 IHC(F/P) 등 다양한 응용에 사용 가능. Affinity chromatography로 정제된 액상 항체이며, 0.5 mg/mL 농도로 제공. CD8 관련 면역학 연구에 적합.
- 카탈로그번호
- 14-0084-xx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD8a Monoclonal Antibody (OX8), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Flow Cytometry (Flow) | 1 µg/test | 4 publications |
| Functional Assay (Functional) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864816 |
Additional Available Formats
- Alexa Fluor 700 (#56-0084-82)
- APC (#17-0084-82)
- eFluor 450 (#48-0084-82)
- FITC (#11-0084-82)
- PE (#12-0084-82)
- PE-Cyanine7 (#25-0084-82)
- PerCP-eFluor 710 (#46-0084-82)
- Super Bright 436 (#62-0084-82)
- Super Bright 600 (#63-0084-82)
- Super Bright 780 (#78-0084-82)
- Custom conjugation available upon request
Product Specific Information
Description:
The OX8 monoclonal antibody reacts with rat CD8 alpha, a member of the immunoglobulin superfamily that forms heterodimers with CD8 beta to create the CD8 antigen. CD8 is expressed on CD4+CD8+ thymocytes, most MHC class I-restricted T cells, and some macrophages. It binds to MHC class I molecules on antigen-presenting cells and participates in T-cell receptor signal transduction via Lck association.
Applications Reported:
- Flow cytometric analysis
- Immunohistology staining of frozen and paraffin-embedded sections
- Functional assays (use Functional Grade purified OX8, Product #16-0084)
Applications Tested:
Tested by flow cytometric analysis of rat splenocytes. Recommended ≤1 µg/test in 100 µL final volume. Optimize titration for best results.
Cell number range: 10⁵–10⁸ cells/test.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein involved in T-cell activation and signal transduction. It functions as a co-receptor for MHC class I molecules and is primarily expressed on cytotoxic T cells, NK cells, monocytes, and dendritic cells. CD8α is essential for MHC-I binding and contributes to CTL activation and pathogen/tumor clearance. Differentiation of CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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