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Thermo Fisher Scientific Chk1 Polyclonal Antibody
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Chk1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. DNA 손상 반응 연구 및 세포 주기 조절 연구에 활용 가능합니다.
- 카탈로그번호
- A300298A
- 판매단위
- pk
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마지막 업데이트 2025. 08. 01. 오후 10:10
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Thermo Fisher Scientific A300298A Chk1 Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
674,500원VAT 포함 741,950원
Thermo Fisher Scientific · Thermo Fisher Scientific Chk1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 250 and 300 of human Checkpoint Kinase 1 (Chk1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in maintaining DNA integrity by halting replication under genotoxic stress. It acts as a key mediator in the DNA damage checkpoint network. Inhibition of CHK1 can induce mitotic catastrophe and apoptosis in p53-deficient cancer cells, while normal cells remain arrested in G1. Thus, CHK1 serves as an attractive therapeutic target for cancer treatment, particularly in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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